TRANSFORMING FACTOR OF BETA TYPE GROWTH.

摘要

A NEW HETERODIMERICA FORM OF THE TGF- (BETA) IS DESCRIBED. THIS MOLECULA KD 25 IS ACTIVE IN IN VITRO TESTS IN THE INHIBITION OF THE GROWTH OF THE EPITHELIAL CELLS. PROTEIN MAY BE ISOLATED FROM THE BONE. WHEN REDUCED, PROTEIN IS LEVIGATED IN TWO PEAKS BY RP-HPLC. THE REDUCED PROTEIN FROM THE EARLIER PEAK OF LEVIGATION REACTS PREDOMINANTLY WITH THE ANTIBODIES DIRECTED AGAINST TGF- (BETA) 3, WHILE THE PROTEIN REDUCED FROM THE PEAK OF REVERSE PREDOMINANTLY BY THE PREVIOUSLY WITH THE )two. THE N-TERM AMINO ACID SEQUENCE AND IMMUNOREACTIVITY OF NATIVE PROTEIN ARE CONSISTENT WITH A HETERODIMER OF TGF- (BETA) 2 AND TGF- (BETA) 3.