CONTROLLED-RELEASE, LOW-DOSE ASPIRIN FORMULATION AND METHOD OF TREATING VASCULAR OCCLUSIVE DISEASE THEREWITH

摘要

An aqueous-based formulation for coating ASAgranules to provide granules that may be compressed intotablets and that show approximately zero-order releasekinetics for release rates of 5 to 15 mg/hour over a periodextending five to eight hours is provided. the coatingformulation preferably consists of an acrylate/methacrylatecopolymer, hydroxypropylmethylcellulose, sodium chloride andtalc. A film-coated tablet comprised of the coatedgranules, filler granules, excipients, binders anddisintegrants is also provided, as are processes forpreparing the tablets and granules and methods for their usein. the treatment of vascular occlusive diseases.