DNA SEQUENCES WHICH CODE FOR VIRULENCE CHARACTERISTICS OF STREPTOCOCCUS SUIS AND PART THEREOF POLYPEPTIDES AND ANTIBODIES DERIVED THEREFROM AND THE USE THEREOF FOR THE DIAGNOSIS OF AND PROTECTION AGAINST INFECTION BY S. SUIS IN MAMMALS, INCLUDING MAN

摘要

The invention provides DNA sequences which code for polypeptides which arecharacteristic for the virulence of thepathogenic bacterium Streptococcus suis and parts thereof, and polypeptidesand antibodies derived therefrom. The sequences codefor a polypeptide of 90.000-120.000 daltons or a polypeptide of highermolecular weight containing such a polypeptide, and for apolypeptide of 135.000-136.000 daltons (muramidase released protein), or partsthereof. The sequences themselves, and also thepolypeptides and antibodies derived therefrom, are used for diagnosis of andprotection against infection by S. suis in mammals,including man.