TREATMENT OF PLATELET DERIVED GROWTH FACTOR RELATED DISORDERS SUCH AS CANCERS USING INHIBITORS OF PLATELET DERIVED GROWTH RECEPTOR

摘要

The present invention concerns compounds which can inhibit platelet derived growth factor receptor (PDGF-R) activity, preferablysuch compounds also inhibit the activity of other members of the PDGF-R super family and are selective for members of the PDGF-Rsuper family. The PDGF-R super family includes PDGF-R and PDCF-R related kinases Flt, and KDR. The featured compounds are activeon cell cultures to reduce the activity of the PDGF-R and preferably one or more PDGF-R related kinases. An example of a featuredcompound, A10 (see Figure 1A), and its ability to inhibit growth of tumor cells in vivo is described below. Using the present applicationas guide other compounds able to inhibit PDGF-R and preferably Flt and/or KDR car be obtained. Such compounds are preferably usedto treat patients suffering from cell proliferative disorders characterized by inappropriate PDGF-R activity.