MODULATION OF TH1/TH2 CYTOKINE EXPRESSION BY RIBAVIRIN.RTM. AND RIBAVIRIN.RTM. ANALOGS IN ACTIVATED T-LYMPHOCYTES

摘要

Ribavirin? is administered to a patient in a dosage range which is effectiveto modulate lymphokine expression in activated T cells. In particular,Ribavirin? is used to suppress Th2-mediated T cell responses and promote Th1-mediated T cell response. In other aspects of the invention, one or moreRibavirin? analogs are administered to a patient in a dosage range which iseffective to modulate lymphokine expression in activated T cells. TheRibavirin? analog(s) may be used to suppress or enhance Th1 or Th2-mediated Tcell responses.