A SINGLE GENE ENCODING AORTIC-SPECIFIC AND STRIATED-SPECIFIC MUSCLE CELL ISOFORMS, ITS REGULATORY SEQUENCES AND USES THEREOF

摘要

Aortic-preferentially-expressed gane-1 (APEG-1) and striated musclepreferentially expressed (SPEG) polypeptide, DNA sequencesencoding and controlling the transcription of the APEG-1'/SPEG encoding gene,methods of diagnosing vascular injury, methods ofconferring smooth muscle-cell specific expression, and methods of inhibitingvascular smooth muscle cell proliferation by increasing thelevel of APEG-1 at the site of vascular injury.