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METHOD OF AFFECTING CHOLESTEROL CATABOLISM USING NUCLEAR BILE ACID RECEPTOR
METHOD OF AFFECTING CHOLESTEROL CATABOLISM USING NUCLEAR BILE ACID RECEPTOR
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机译:利用核胆汁酸受体影响胆固醇代谢的方法
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摘要
The present invention relates to methods and compositions for modulating geneswhich are controlled by the FXR orphan nuclear hormone receptor. In apreferred embodiment, the method involves modulation of the gene encodingCyp7a, the enzyme responsible for a major pathway in the elimination ofcholesterol. The invention also relates to methods for screening compoundswhich bind to and activate or inhibit the FXR nuclear hormone receptor.
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