HUMAN PROTEIN KINASE B.GAMMA. POLYPEPTIDES AND A METHOD FOR DISRUPTING PROTEIN KINASE B.GAMMA. IN A NON-HUMAN

摘要

The present invention relates to human protein kinase B .gamma. polypeptidesand to nucleic acid molecules coding for such polypeptides. The inventionfurther relates to vectors and cells comprising said nucleic acid molecules,as well as to methods for screening test compounds which affect the insulinsignaling pathway. In contrast to the previously known protein kinase B.gamma. from rat brain, the human protein kinase B .gamma. polypeptidescomprise two activating phosphorylation residues; Thr305 and Ser472.