A novel anti-angiogenic agent comprising at least one kringle region and an upstream pre-activation domain of plasminogen

摘要

The present invention relates to compositions that inhibit the proliferation and migration of endothelial cells. The compositions contain a pre-activation domain ("PAD") from plasminogen, or a biologically active fragment thereof, and at least one kringle region from plasminogen, or a biologically active portion thereof. The compositions are useful to treat angiogenic associated disorders.