Injectable collagen-based delivery system for bone morphogenic proteins

摘要

Disclosed herein is a method for delivering a bone morphogenic protein to a tissue site, the method involving: (a) combining the bone morphogenic protein (BMP) with a soluble collagen; and (b) administering the BMP-collagen solution to the tissue site, whereby, upon contact with the tissue, the collagen solution is converted to a collagen gel. Also disclosed herein is the use of this method for treating bone or cartilage defects, as well as useful BMP-collagen solutions.