首页>
外国专利>
Methods and compositions relating to modulation of cartilage cell growth and/or differentiation by modulation of nfatp activity
Methods and compositions relating to modulation of cartilage cell growth and/or differentiation by modulation of nfatp activity
展开▼
机译:与通过调节nfatp活性来调节软骨细胞生长和/或分化有关的方法和组合物
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention demonstrates that NFATp represses cartilage cell division and represses the chondrogenic program in cells and displays the properties of a tumor suppressor gene. In addition, the invention demonstrates that inhibition of NFATp activity promotes cartilage cell proliferation and differentiation. Methods for identifying modulators of cartilage growth and/or differentiation, using either NFATp-deficient cells or NFATp-containing indicator compositions, are provided. Methods of modulating cartilage cell growth and/or differentiation using agents that modulate the activity of NFATp are also provided. Methods for diagnosing disorders associated with aberrant cartilage cell growth and/or differentiation, by assessing a change in NFATp expression, are also provided.
展开▼