Polyethylene glycol-polyorthoester, polyethylene glycol-polyorthoester-polythylene glycol, and polyorthoester-polyethylene glycol-polyorthoester block copolymers
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机译:聚乙二醇-聚原酸酯,聚乙二醇-聚原酸酯-聚乙二醇和聚原酸酯-聚乙二醇-聚原酸酯嵌段共聚物
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摘要
PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents, especially when the POE block(s) contain at least one unit containing an alpha -hydroxy acid.
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