The present invention relates to a (pharmaceutical) composition comprising a circulating blood cell, preferably a monocyte loaded with a therapeutically active molecule and, optionally, a pharmaceutically acceptable carrier and/or diluent. Furthermore, the present invention relates to the use of a circulating blood cell, preferably a monocyte loaded with a therapeutically active molecule for the preparation of a (pharmaceutical) composition for enhancing collateral growth of collateral arteries and/or arteries from pre-existing arteriolar connections and/or preventing and/or treating an occlusive disease. The present invention also relates to a method for enhancing collateral growth of collateral arteries and/or arteries from pre-existing arteriolar connections, and/or preventing and/or treating an occlusive disease, said method comprising administering to a subject in need thereof an effective amount of circulating blood cells, preferably monocytes loaded with a therapeutically active molecule. Also described are (pharmaceutical) kits, diagnostic compositions, their preparation and use as well as diagnostic methods.
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