Recognition of protein coding regions in genomic dna sequences

摘要

A coding sensor using a recurrent neural network technique is provided. The coding sensor indicates the coding potential of a gene sequence and plays a vital role in the overall prediction of the gene structure. The recognition of the potential coding regions in a DNA sequence may be achieved by determining whether each individual nucleotide position in a nucleotide chain is in a coding region. Determining whether an individual nucleotide position is in a coding region may be accomplished through a systematic sampling process carried out along the nucleotide chain from start to end. The content variables of neighboring nucleotide positions are processed using a trained recurrent neural network in order to provide a coding sensor value. In this way, transition characteristics may be used to assist the coding sensor in determining whether a nucleotide position is in a coding region. The coding sensor value represents a prediction of whether or not the nucleotide position is in a coding region. Coding sensor values for each nucleotide position in the DNA sequence are aligned with the overall DNA sequence to generate a coding/non-coding picture of the DNA sequence.