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Cytoplasmic modulators of integrin regulation/signaling
Cytoplasmic modulators of integrin regulation/signaling
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机译:整合素调节/信号传导的细胞质调节剂
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摘要
The present invention provides purified and isolated polynucleotides encoding IRP (Integrin Regulatory Protein) polypeptides which regulate beta2 and beta7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes.
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