CALCINEURIN-DEPENDENT CONTROL OF SKELETAL MUSCLE FIBER TYPE

摘要

The present invention relates to skeletal muscle fiber composition. More particularly, the present invention defines the molecular events linking calcium stimulation to specialization of skeletal muscle fibers. More specifically, the present invention shows that Ca2+ stimulation of the slow fiber phenotype is mediated through a calcineurin-dependent pathway. Thus, the present invention provides methods and compositions for altering and/or regulating the phenotype of muscle. Further provided are methods for the detection of compounds having therapeutic activity toward regulating muscle fiber composition.