COSMETIC OR DERMOPHARMACEUTICAL USE OF PEPTIDES FOR HEALING, HYDRATING AND IMPROVING SKIN APPEARANCE DURING NATURAL OR INDUCED AGEING (HELIODERMIA, POLLUTION)

摘要

The invention concerns the use of peptides of general sequence X-Thr-Thr-Lys-Y, wherein in particular X = lysine and Y = serine, in cosmetic or dermopharmaceutical compositions. It is moreover advantageous to use said peptides in mutual combination. In order to enhance their activity and their stability, the peptides are chemically modified to increase their lipophilicity, by grafting on the N-terminal amine of X, either a fatty acid chain, or by esterification or amidation of the C-terminal carboxyl group of Y. The peptides can be obtained by synthesis, biotechnology or controlled hydrolysis or plant proteins. The resulting compositions are advantageously used for stimulating healing, hydrating or all skin treatments. They are particularly active against formation or deterioration of wrinkles and against all the consequences of skin ageing, whether natural or induced (heliodermia, pollution), as well as for dry skin.