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A METHOD FOR TARGETED DEGRADATION OF INTRACELLULAR PROTEINS IN VIVO OR $i(EX VIVO)
A METHOD FOR TARGETED DEGRADATION OF INTRACELLULAR PROTEINS IN VIVO OR $i(EX VIVO)
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机译:一种体内或体内$ i(EX VIVO)有针对性降解细胞内蛋白的方法
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摘要
A method for in vivo selective targeted degradation of intracellular proteins in situ by inducing in vivo or ex vivo in cells a production of dual-function protein comprising N-terminal domain as well as a C-terminal domain or delivering the dual-function protein. The N-terminal domain of the dual-function protein destabilizes the target protein and directs its degradation when linked to it through a linker between the target protein and between the protein agent of the invention. The protein degradation directing N-terminal domain is a subregion within the first 97 amino acids corresponding to the N-terminus of protein antizyme.
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