A deletion type C DELTA P16 protein in which the carboxy terminal of P16, which is an inhibitor of CDK4, is cleaved,

摘要

The present invention relates to a truncated C P16 protein and its gene whose carboxy terminus has been cleaved of p16 protein, an inhibitor of CDK4 (cell cycle dependent kinase 4). Specifically, the present invention relates to a defective Cp16 protein whose 21 carboxy terminal amino acids have been cleaved from a p16 protein that is an inhibitor of human CDK4, a gene thereof, an expression vector comprising the same, and a recombinant baculovirus. Since the protein is small in size and maintains the same activity as the p16 protein, it can be used for analyzing the crystal structure of the CDK4 / p16 complex, studying the mechanism of action of CDK4, and developing an anticancer drug.