BIODEGRADABLE POLYSACCHARIDE SPONGE TYPE FORMULATION CONTAINING TISSUE GROWTH FACTORS FOR OSTEOBLAST IMPLANTATION TO RECOVER

摘要

The present invention relates to a preparation for osteoblast transplantation for the restoration of periodontal tissue, and more specifically, a biodegradable cell transplant preparation for restoration of periodontal tissue containing osteoblasts and histological factors in a sponge- made of chitosan. It is about.;The present invention is characterized in that the surface of the sponge made of chitosan is crosslinked with sodium tripolyphosphate, and the tissue growth factor or inorganic material is contained therein so as to attach and proliferate osteoblasts, so that it can be used for transplantation of osteoblasts.;In the present invention, the cells are attached by chitosan constituting the sponge, and the inorganic or tissue growth factors contained therein are gradually released to allow the cells to proliferate and differentiate. After the differentiation, the sponge is completely decomposed by lysozyme in vivo.