DEAZA-SPIRO(4.5) decant DERIVATIVE OR TRIAZA-SPIRO(4.5) decant DERIVATIVE

摘要

PURPOSE: A derivative is provided to treat a uneasiness, a stress disorder, a melancholia, a loss of memory caused by a senilis, an artilerosclerosis, and an obesity efficiently. CONSTITUTION: A diaza-spiro(4.5) decant derivative and a triaza-spiro(4.5) decant derivative manufactured for having an affinity to the OFQ-receiver with a range of 7.1¯9.8 is obtained by: R1 which is C6-10-cycloalkyl optionally substituted by low grade alkyl or -C(O)O-low grade alkyl; R2 which is =O or phenyl substituted by hydrogen; low alkyl; low alkyl, halogen, or alkoxy; X which is -CH(OH)-; -C(O); Y which is -CH2-; -CH=; and a or b which is an optionally additional combination.