PREPARATION OF 1S-1A,2B,3B,4A(S*)-4-7-1-(3-CHLORO-2-THIENYL) METHYLPROPYLAMINO-3H-IMIDAZO4,5-BPYRIDIN-3-YL-N-ETHYL-2,3-DIHYD ROXY

摘要

PURPOSE: Methods for the preparation of £1S-£1a,2b,3b,4a(S*)| |-4-£7-££1-(3-chloro-2-thienyl)methyl|propyl|amino|-3H-imidazo£4,5-b|pyridin-3-yl|-N-et hyl-2,3-dihydroxycyclopentanecarboxamide, methods for the preparation of intermediates thereto, and the intermediates themselves, are provided. CONSTITUTION: A method for preparing £1S-£1a,2b,3b,Aa(S*)||-4-£7-££1-(3-chloro-2- thienyl)methyl|propyl|amino|-3H-imidazo£4,5-b|pyridin-3-yl|-N-ethyl-2,3-3-dihydroxycycl opentanecarboxamide represented by compound (I), comprises reacting £1S-£1a,2b,3b,4a(S*)||-4-££3-amino-4-£1£3-chloro-2-thienyl)methyl|propyl|amino|-2-pyddin yl|amino|-N-ethyl-2,3-dihydroxycyclopentanecarboxamide with an orthoformate ester, formamidine acetate, or dimethylformamide dimethyl acetal.