BICYCLIC DERIVATIVES OF AMIDINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF NITROGEN OXIDE SYNTHETASE ACTIVITY

摘要

FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes bicyclic derivatives of amidine of the formula (I) where D means five-membered heterocyclic aromatic ring containing from 1 to 4 heteroatoms taken among O, N or S and optionally substituted by carbon atom with halogen atom, trifluoromethyl, C_1-6-alkyl, nitro- or cyano-group and bound with other moiety of compound of the formula (I) through carbon atom; A means N(X) or CH (-(CH₂)_m-NXY); U means NH, O or CH₂; V means (CH₂)_a; W means (CH₂)_b; a, b, m, X and Y have values given in the invention claim. Invention describes also methods of synthesis of compounds and preparing the pharmaceutical composition containing thereof. Compounds of the formula (I) are inhibitors of nitrogen oxide synthetase activity and can be used in therapy. EFFECT: improved method of synthesis, valuable biochemical and therapeutic properties of compounds. 10 cl