, their pharmaceutically acceptable salts where R1 and R2 in common with binding their double bond mean phenyl or pyridyl ring or ring of the formula (A) where R8 means hydrogen atom, C1-C4-alkyl; R1, R4 in common with their binding double bond mean phenyl ring or four-eight-membered cycloalkene residue being indicated for R1/R2 and R3/R4 rings are unsubstituted or substituted with 1-3 similar or different substituents taken among the group including CF3, C1-C6-alkoxy-group, C1-C6-alkoxycarbonyl-group, C1-C6-alkyl and the latter can be substituted with hydroxy-group; D is hydrogen atom, C4-C12-cycloalkyl, C1-C12-alkyl; E is group CO- or CS; L is O, S, -NR9; R9 is hydrogen atom, C1-C6-alkyl possibly substituted with phenyl, hydroxy-group; R5 is phenyl, pyridyl, thienyl that can be substituted; R6 is hydrogen atom, carboxy-group, C1-C5-alkoxycarbonyl-group, C1-C6-alkyl that can be substituted with hydroxy-group, -O-CO-R15; R15 is possibly substituted phenyl, C1-C22-alkyl, C2-C22-alkenyl; R7 is hydrogen atom; R6 and R7 in common mean group of the formula = O. Invention describes also intermediate compounds and pharmaceutical composition inhibiting the release of lipoproteins associated with apolipoprotein B-100. EFFECT: new compounds indicated above, valuable pharmacological properties. 5 cl, 35 tbl, 192 ex"/>
DERIVATIVES OF CYCLOALKANOINDOLE AND AZAINDOLE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, DERIVATIVES OF CARBOXYLIC ACID AS PARENT COMPOUNDS AND PHARMACEUTICAL COMPOSITION INHIBITING RELEASE OF LIPOPROTEINS ASSOCIATED WITH APOLIPOPROTEIN B-100
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DERIVATIVES OF CYCLOALKANOINDOLE AND AZAINDOLE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, DERIVATIVES OF CARBOXYLIC ACID AS PARENT COMPOUNDS AND PHARMACEUTICAL COMPOSITION INHIBITING RELEASE OF LIPOPROTEINS ASSOCIATED WITH APOLIPOPROTEIN B-100
DERIVATIVES OF CYCLOALKANOINDOLE AND AZAINDOLE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, DERIVATIVES OF CARBOXYLIC ACID AS PARENT COMPOUNDS AND PHARMACEUTICAL COMPOSITION INHIBITING RELEASE OF LIPOPROTEINS ASSOCIATED WITH APOLIPOPROTEIN B-100
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel derivatives of cycloalkanoindole and azaindole, mixture of their isomers and separate isomers of the general formula (I) , their pharmaceutically acceptable salts where R1 and R2 in common with binding their double bond mean phenyl or pyridyl ring or ring of the formula (A) where R8 means hydrogen atom, C1-C4-alkyl; R1, R4 in common with their binding double bond mean phenyl ring or four-eight-membered cycloalkene residue being indicated for R1/R2 and R3/R4 rings are unsubstituted or substituted with 1-3 similar or different substituents taken among the group including CF3, C1-C6-alkoxy-group, C1-C6-alkoxycarbonyl-group, C1-C6-alkyl and the latter can be substituted with hydroxy-group; D is hydrogen atom, C4-C12-cycloalkyl, C1-C12-alkyl; E is group CO- or CS; L is O, S, -NR9; R9 is hydrogen atom, C1-C6-alkyl possibly substituted with phenyl, hydroxy-group; R5 is phenyl, pyridyl, thienyl that can be substituted; R6 is hydrogen atom, carboxy-group, C1-C5-alkoxycarbonyl-group, C1-C6-alkyl that can be substituted with hydroxy-group, -O-CO-R15; R15 is possibly substituted phenyl, C1-C22-alkyl, C2-C22-alkenyl; R7 is hydrogen atom; R6 and R7 in common mean group of the formula = O. Invention describes also intermediate compounds and pharmaceutical composition inhibiting the release of lipoproteins associated with apolipoprotein B-100. EFFECT: new compounds indicated above, valuable pharmacological properties. 5 cl, 35 tbl, 192 ex
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