New imidazotriazine derivatives useful as smooth muscle relaxants for treating e.g. cardiovascular disorders, cerebrovascular disorders, or erectile dysfunction

摘要

2-Sulfamoylphenyl-5-alkyl-7-(cyclo)alkyl-4(3H)-imidazo(5,1-f)(1,2,4)tr iazinone derivatives (I) are new. 2-Sulfamoylphenyl-5-alkyl-7-(cyclo)alkyl-4(3H)-imidazo(5,1-f)(1,2,4)tr iazinone derivatives of formula (I) are new: R1 = 1-4C alkyl; R2 = 5-20C alkyl or 3-8C cycloalkyl; R3, R4 = H; 2-8C alkenyl; 1-10C alkyl optionally interrupted by an O atom and optionally substituted by 1-3 of CF3, OCF3, OH, halogen, COOH, benzyloxycarbonyl, 1-6C alkoxy, 2-6C alkoxycarbonyl, 1-6C alkylthio, SO3H, etc; or NR3R4 = optionally substituted optionally benzo-fused 5-7 membered heterocyclic group; or NR3R4 = a (bi)(hetero)cyclic group; and R5, R6 = H, 1-6C alkyl, OH or 1-6C alkoxy. Full definitions given in the 'Definition' section. An Independent claim is also included for the preparation of (I).