Manufacture of active preparations comprises cross linking a protein, which surrounds the active substance with an enzyme, especially a novel lysyl oxidase from Pichia pastoris

摘要

A method to manufacture a preparation of an active substance is new, where the active substance is surrounded by at least one layer consisting of a protein that is cross-linked by an enzyme chosen from the group of lipoxygenase, protein disulfide isomerase, phenol oxidase and peroxidase, lysyl oxidase, protein disulfide reductase, tyrosine oxidase or sulfhydryl oxidases. Independent claims are also included for: (1) an active substance preparation prepared by a method as above; and (2) an isolated protein comprising at least one of the 12 sequences given in the specification.