A novel aspartate protease, coding sequence, inhibitors and antibodies, useful for treatment and diagnosis of Alzheimer's disease

摘要

A novel aspartate protease (AP) has two aspartate residues in a catalytically active structure, where the first aspartate residue is present in motif (I) and a second aspartate residue is present in motif (II), where (I) and (II) are present in a transmembrane region. A novel aspartate protease has two aspartate residues in a catalytically active structure, where the first aspartate residue is present in motif (I) and a second aspartate residue is present in motif (II): where (I) and (II) are present in a transmembrane region. X1, X2, X3, X5 = Ala, Val, Leu, Met, Ile chosen independently from one another; X4 = an aromatic amino acid . Independent claims are also included for the following: (1) a nucleic acid sequence encoding (AP); (2) compounds that inhibit expression or activity of (AP); (3) an antibody targeted against (AP); and (4) a method to identify inhibitors of the aspartate protease activity.