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substituted chromanylsulfonyl (thiometon) urea, process for their manufacture and their use in pharmaceutical preparations, and pharmaceutical preparations containing them
substituted chromanylsulfonyl (thiometon) urea, process for their manufacture and their use in pharmaceutical preparations, and pharmaceutical preparations containing them
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机译:取代的苯并二氢吡喃磺酰基(硫磺)尿素,其制备方法及其在药物制剂中的用途以及含有它们的药物制剂
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摘要
N-(4-Amidoalkyl-chroman-5-yl-sulphonyl)-urea or -thiourea derivatives of formula (I) and their salts are new. R1 = H, alkyl, alkoxy, F, Cl, Br, I, CF3, NH2, mono- or dialkylamino or alkylthio; R2a = H, Me or Et; R2b, R2d = H, Me or Et; or phenyl or benzyl (both optionally ring-substituted by 1-3 of halogen, Me, Et, OMe and OEt); R2c,R2e = H, Me or Et; R3 = H, alkyl, cycloalkyl, cycloalkylmethyl or CF3; n = 1 or 2; Z = O or S; A = phenyl (optionally substituted by 1-3 of halogen, Me, OMe, Et or OEt), a lactam residue of formula (a), 1-oxo-1,2,3,4-tetrahydroisoquinolin-2-yl, 1-oxo-per-hydro-isoquinolin-2-yl, 1-oxo-1,2-dihydro-iso-indol-2-yl or 1-oxo-per-hydro-iso-indol-2-yl; B = 3-6C alkylene or 3-6C alkenylene (both optionally substituted by 1-3 alkyl); unless specified otherwise alkyl moieties have 1-4C and cycloalkyl moieties 3-6C.
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机译:式(I)的N-(4-氨基烷基-苯并二氢吡喃-5-基-磺酰基)-脲或-硫脲衍生物及其盐是新的。 R1 = H,烷基,烷氧基,F,Cl,Br,I,CF3,NH2,单或二烷基氨基或烷硫基; R 2a = H,Me或Et; R2b,R2d = H,Me或Et;或苯基或苄基(均任选被1-3个卤素,Me,Et,OMe和OEt环取代);或R2c,R2e = H,Me或Et; R3 = H,烷基,环烷基,环烷基甲基或CF3; n = 1或2; Z = O或S; A =苯基(可选被1-3个卤素,Me,OMe,Et或OEt取代),式(a)的内酰胺残基,1-氧代-1,2,3,4-四氢异喹啉-2-基,1 -氧-过氢-异喹啉-2-基,1-氧-1,2-二氢-异吲哚-2-基或1-氧-过氢-异吲哚-2-基; B = 3-6C亚烷基或3-6C亚烯基(均任选被1-3个烷基取代);除非另有说明,否则烷基部分具有1-4C且环烷基部分具有3-6C。
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