首页>
外国专利>
MODULATION OF GENE EXPRESSION BY INTERVENTION IN THE RNA SECONDARY STRUCTURE
MODULATION OF GENE EXPRESSION BY INTERVENTION IN THE RNA SECONDARY STRUCTURE
展开▼
机译:RNA二级结构中干扰基因的表达调控
展开▼
页面导航
摘要
著录项
相似文献
摘要
Methods for modulating the expression of genes are disclosed comprising selecting a portion RNA coded by the gene, said RNA portion having subportions forming a secondary structure, and contacting the RNA with oligonucleotide or oligonucleotide analog which can bind with at least one said subportions of the RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind to RNA secondary structures which are of significance to the expression of the gene coding for said RNA. In accordance with a preferred embodiment, methods of treatment of human immunodeficiency virus are similarly disclosed wherein the oligonucleotides or oligonucleotide analogs are targeted at the TAR, CAR or gag-pol elements of HIV. IMAGE IMAGE
展开▼