Burt of the invention, it is provided to check of malformations the chromosomes

摘要

PURPOSE: To perform antenatal screening for chromosomal abnormalities by determining the various gestational ages by reference to the last menstrual period dates and by a biometric measurement of the foetus, the difference between the ages is calculated and the calculated difference is examined using reference data to determine fetal abnormalities. ;CONSTITUTION: The various gestational ages of a pregnant woman are determined by reference to the last menstural period dates and by a biometric measurement of the foetus, the difference between the ages is calculated and the calculated difference is examined using reference data to determine fetal abnormalities. If the gestational age evaluated by a biometric measurement is lower than the value calculated by reference to the last menstrual period dates, there is the likelihood of sluggish growth in uterus. In the case that the sluggish growth is related to chromosomal and other abnormalities, for instance, the difference of the gestational age is about two weeks between a foetus having No. 18 trisomy syndrome and an average foetus. This method is applicable to antenatal screening for a wide range of chromosomal abnormalities, and is useful particularly for detecting Edward's syndrome, open binary fission of spine and Patau's syndrome.;COPYRIGHT: (C)1994,JPO