5,6-Dihydro imidazo benzazepine acetic acid derivatives as complete or partial agonists of GABA A receptors containing alpha 1, 2, 3, or 5 sub-units having hypnotic, anesthetic, anxiolytic, and anti-convulsant activity

摘要

5,6-Dihydro-4H-imidazo(1,2-a)(1) benzazepine acetic acid derivatives (I) are new. 5,6-Dihydro-4H-imidazo(1,2-a)(1) benzazepine acetic acid derivatives of formula (I), their optical isomers and their salts are new. X = H, halo, CN, methyl, ethyl, 1-hydroxy ethyl, vinyl, methoxy, OH, acetyloxy, propylamino carbonyloxy, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, acetyl, methylamino carbonyl, dimethylamino carbonyl, phenyl, furan-2-yl, thien-2-yl, or pyridin-2-yl; Y' = H, Cl, 1 or 2 methyl, or methoxy; Z = H or -CH2-COOR1, -CH2-CONR2R3; R1, R2 = H, 1-4C alkyl; R3 = 1-4C alkyl; or NR2R3 = pyrrolidinyl or piperidinyl.