New erythromycin derivative useful for treating bacterial infections from gram-positive bacteria e.g. staphylococcus, streptococcus or pneumoccocus

摘要

Erythromycin derivatives (I) are new. Erythromycin derivatives of formula (I) are new. R = (CH2)mOn(X)YAr X = (NH)a, CH2 or SO2; Y = (CH2)b-(CH=CH)c-(CH2)d; m, n, a, c = 0 or 1; b + c + d = less than 8; Z = H or halo; Ar = aryl or heteroaryl (optionally substituted); R1 = H or methyl; and W1 = H or acyl. An Independent claim is also included for the preparation of (I).