Hair growers having actions of promoting proliferation of hair papilla cells

摘要

Astragali radix extract, which was used as a starting material, was purified over various kinds of column chromatography (activated carbon, Amberlite IR-120B [H.sup.+ ], cellulose, Sephadex G25 and HPLC) to isolate a peptide as a white powder. This peptide is a water-soluble neutral substance and shows positive reactions to ninhydrin and sodium nitroprusside and negative reactions to anisaldehyde, phenolsulfuric acid and Dragendorff reagent. Amino acids constituting the peptide of the present invention contain aspartic acid and oxylysine in large amounts. The peptide of the present invention were successful in promoting 150% proliferation of rabbit hair papilla cells when applied in a concentration of 1.4 &mgr;g/ml.