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Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally- acting opioid agonists
Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally- acting opioid agonists
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机译:同时提高由吗啡和其他双峰作用的阿片类激动剂引起的镇痛作用和减轻依赖性的方法
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摘要
This invention relates to a method for selectively enhancing the analgesic potency of a bimodally-acting opioid agonist such as morphine and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of the bimodally-acting opioid agonist. The method of the present invention comprises administering to a subject an analgesic or sub-analgesic amount of a bimodally-acting opioid agonist such as morphine and an amount of an excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of the bimodally-acting opioid agonist and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of the bimodally-acting opioid agonist.
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