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Dithiolopyrrolones and their corresponding monooxides and dioxides as antitumor agents
Dithiolopyrrolones and their corresponding monooxides and dioxides as antitumor agents
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机译:二硫代吡咯烷酮及其相应的一氧化物和二氧化物作为抗肿瘤剂
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摘要
Compounds, isolated from the bacteria Xenorhabdus bovienii, having formula (1), wherein R1 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, or heterocyclyl group; R2 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or group acyl; R3 = hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclyl group, or (2), wherein R1 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, or heterocyclyl group; R2 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or group acyl; R3 = hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclyl group, or (3), wherein R1 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, or heterocyclyl group; R2 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or group acyl; R3 = hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclyl group or the salts thereof have antineoplastic activity. The invention provides pharmaceutical compositions containing the compounds and the methods for employing them as medicaments, particularly in the treatment of human and animal cancers.
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