Compositions and methods for modulating NF-κB activation in cells

摘要

Compositions and methods for modulating the activation of nuclear factor kappa B (NF- kappa B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I kappa B alpha and/or I kappa B beta . Such compositions may be used for treating diseases associated with NF- kappa B activation. Modulating agents include peptides that comprise a recognition domain for E3 ubiquitin ligase.