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PROMOTER FOR MODULATING EXPRESSION OF AGGRECANASE 1 (ADAMTS4)
PROMOTER FOR MODULATING EXPRESSION OF AGGRECANASE 1 (ADAMTS4)
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机译:调节表达集脂酶1(ADAMTS4)的启动子
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摘要
PROBLEM TO BE SOLVED: To construct a system for screening a compound which controls the transcription of aggrecanase 1 gene related to various diseases, clones a promoter domain, elucidates a base sequence and affects the expression of aggrecanase 1.;SOLUTION: A base sequence of a promoter domain at the upstream of an aggrecanase 1 gene is elucidated, a vector in which a reporter gene is connected to the downstream of the promoter domain of the aggrecanase 1 gene or a promoter domain deficient in a part of the promoter gene is prepared, transferred to a mammalian cell and the compound affecting the expression of aggrecanase 1 can be screened.;COPYRIGHT: (C)2001,JPO
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