Destruction of proteins associated with mammalian Rad51 and Rad51 destruction of mammalian proteins to inhibit cell proliferation

摘要

Finger called mutation (57) [summary] and rad51 ^M1 is generated in MmRAD51 gene mouse mutant embryos die immediately after transplantation. cell death decreased hypersensitivity to ionizing radiation, of proliferation, programmed, and rad51 ^M1 cells exhibit chromosome loss. Viability of the cells and are stopped and / or a decrease in cell proliferation by disruption of protein interactions - MmRad51 protein. For example, some proteins that interact with MmRad51 such as M96 and Brca2 have been identified. In addition, Rad51 self coupled via a N- terminal region. The changes in alanine lysine residues single stored to be toxic to the cells was found to change. In addition, rad51 allele lacking the RecA homology region was also detrimental to the cell. That the viability and / or cellular proliferation is inhibited by the terms of these, you can either inhibit the function of MmRad51, to inhibit the function of the molecule of any of the Rad52 pathway or Rad51 or any molecule that binds to MmRad51 is clear is. Therefore, to obtain molecules which are able to block important DNA repair pathways these are useful as therapeutic agents to inhibit cell proliferation.