The improvement in this regard or in contrast agent

摘要

A combined preparation for simultaneous, separate or sequential use as a contrast agent in ultrasound imaging comprises: (i) an injectable aqueous medium having gas dispersed therein; and (ii) a composition comprising a diffusible component capable of diffusion in vivo into the dispersed gas so as to increase the size of the gas at least transiently. Also claimed is the method of generating enhanced images of a subject which comprises: (i) injecting an aqueous medium with a gas dispersed therein into the vascular system of the subject; (ii) before, during or after the injection of the aqueous medium, administering a composition comprising a diffusible component capable of increasing the size of the gas, at least transiently; and (iii) generating an ultrasound image of at least a part of the subject.