LACTOBACILLUS EXTRACT AND KILLED BACTERIUM CELL POWDER WHICH ARE ORIGINATED FROM ENTERIC BACTERIUM AND HAVE FUNCTION FOR PREVENTING INFECTIOUS DISEASE AND FUNCTION FOR REDUCING DISEASE RELATED TO IMMUNITY AND THEIR APPLICATION TO FOOD

摘要

PROBLEM TO BE SOLVED: To obtain an immunomodulator from which protection against the internal infection of Escherichia coil, Bacillus dysentericus and Salmonella and the prevention and reduction of rheumatic arthritis and immune-related diseases such as Crohn disease and ulcerative colitis can be expected and which is useful as a safe raw material for foods, by including the killed cells of a specific lactobacillus as an active ingredient. SOLUTION: This immunomodulator contains the killed cells of Enterococcus faecalis AD101 strain (international accession number BP-297) as an active ingredient. The killed cells are preferably taken at a daily dose of 50 mg to 1 g as dry weight for man. The immunomodulator is preferably produced by a method comprising washing the Enterococcus faecalis AD101 strain with water such as distilled water, suspending the washed cells in water, subjecting the cells to a hot water-heating sterilization treatment at 60 to 125 deg.C for 1 to 60 min, and, if necessary, then drying the sterilized cells into powdery fine particles by a spray-drying method, a freeze-drying method or the like.