Complex of bis - Platinum (ii), method for preparing the compound and Use thereof in the preparation of a Pharmaceutical composition for treating tumors.

摘要

This paper introduces the diplatinum (II) complex containing polyimide derivatives, the method of developing the complex and the method of developing the polyimide derivatives. These buildings answer a questionTwo of the platinum nuclei linked by X and YZ are ammonia, while otroligando is selected from the groups of chlorination, bromine, iodine and C1-4 acid Xi; m and N are independent integers 2 to 8; P is an integer, which can be 1 or 2; A selected from the group consisting of - b1-y-b2 - (CH2) r-b2 -.R is an integer, ranging from 2 to 8; B1 is selected from the group consisting of - nr1-co -,CO-NR1, NR1-SO2-NR1, -NR1-C (= NR2) -NR1, -NR1-CO-CO-NR1 or NR 1-CO-NR1 and B2 is a group -NR1-CO or -CO-NR1, where R1 is hydrogen or a C1-4 alkyl group and R2 has the values of R1 or is a tert-butyloxycarbonyl group, and Q (-P) is a union selected from chloride, bromide, iodide, nitrate, sulfate, acid sulfate and perchlorate. Such bis-platinum complexes are useful in the treatment of tumors in mammals.