Process to prepare a base of (+) - norcisapride ((+) - 4 - amino - 5 - Chloro - N - (3 - (4 - methoxy piperidinil) - 2 - metoxibenzamida), The Compound, Salt thereof, Pharmaceutical composition containing itProcess for preparing the composition, its use for the manufacture of a Medicament and compounds

摘要

A process to prepare a base of (+) - norcisapride ((+) - 4 - amino - 5 - Chloro - N - (4 - methoxy - 3 - 2 - metoxibenzamida piperidinil) of formula (i) comprising: (a) to separate the Enantiomers of cis - Ethyl 4 - (AMIno - 5 - Chloro - 2 - methoxy - benzoylamino) - 3 - methoxy - 3 - carboxylate piperidin through the cromatografu00edalu00edquida on a Chiral stationary Phase, and (b) Isolating The fraction that is dextrorotatorio,And (c) to (+) The fraction solvolizar - norcisapride; dichocompuesto, Salt thereof, Pharmaceutical composition containing itProcess for preparing the composition for use in the manufacture of a medicamentopara Treat Gastrointestinal Disorders whileAt the same time Preventing effects on the central nervous system and compuestosintermediarios for exclusive use in this process.In view of its activity 5-ht3 antagonist, (+) - norcisopride is useful for the treatment of disorders associated with over Stimulation of the activity of the 5-ht3 receptor, e.g.Vomiting, for example vomiting induced by a Drug and radiation etotoxica, irritable bowel syndrome, especially with diarrhea predominant irritable bowel syndrome.And trastornosrelacionados.