Polypeptide compounds useful for the treatment of microbial Infections, Process for preparing them,Compositions that include Drugs and the use of such compounds and Method for prophylactic and therapeutic Treatment of infections

摘要

This polypeptide compounds represented by the General formula (i) wherein: R1 is Hydrogen; arilamino alcanoilo (Lower) can have one or more appropriate Substituent (S) (S); aroilo replacementGone with a group that can teneruno Heterocyclic Substituent (S) or right (S); aroilo substituted alkyl conarilo has higherAroilo substituted aryl alkyl aryl is lower: alcanoilo (C2 - 6) has alquiloinferior substituted with aryl,Alcanoilo Lower unsaturated Heterocyclic condensate sustituidocon Group can have one or more appropriate Substituent (S) (S); alcanoiloinferior substituted piridilo can have one or moreAppropriate Substituent (S) (S) amino Group hexilnaftoilo, heptilnaftoilo protector;Aroilosustituido with carbamoilo can have one or more Heterocyclic Substituent (S) (S) alcanoilo replaced with lower Cycle (Lower alkyl) may have one or more Substituent (S)Right (S); alcanoiloinferior is replaced with tienilo Group that can teneruno Heterocyclic Substituent (S) or right (S); or alquenoilo Lower substituted Heterocyclic Group thatYou can have one or more appropriate Substituent (S) (S) r2es; R3 is Hydrogen, Hydroxy, alkoxy or Hydroxy, hidroxisulfoniloxi Lower.Hydroxy or alkoxy and R4 is lower, or one of its Salts which have actividadesantimicrobianas (especially Antifungal Activities), Inhibitory activity on 1,3 glucan synthase.Seproponen also the preparation of the same and / or Pharmaceutical compositions and Methods for the therapeutic or prophylactic Treatment of Infectious DiseasesDepneumocystis carinil including infection (e.g. carinil Pneumocystis pneumonia in humans and animals.