A Chimeric Nucleic Acid Molecule to induce Self regulated apoptosis in inflammatory cells, a process for their PreparationUnacomposicion Pharmaceuticals containing such a Molecule, and a method for treating an inflammatory disorder using such compositions, and Methods

摘要

A chimeric acid molecule comprising: at least one TNFalfa promoter booster region linked to a TNFalfa promoter, the booster region comprising SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 11, SEQ ID NO: 12 nucleic acid or a conservative substitution or allelic variants thereof; the TNF alpha promoter is also attached or a nucleic acid sequence encoding the Granzyme B protein or a conservative substitution or allelic variants thereof, which, in turn,They are related to a series of 3utr nucleic acids A drug synthesis method containing the above-mentioned chemical nucleic acid molecules, a method for treating a combustible disorder, which can be understood by a patient who needs such treatmentComment more than a month ago A process for manufacturing chemical nucleic acid molecules, including at least one tnfalf initiator enhancer, plus a functional copy of the smallest tnfalf regulator, plus at least one copy of the moldy induced nucleic acid moleculesfunctionIn addition, there is a nucleic acid sequence tnfalfa-3utr. In this sequence, the expression of the nucleic acid leading to aputosis is driven by the initiator of tnfal. The program includes: (a) expanding a nucleic acid molecule through chain reaction, including a tnfafa initiator a. (b) clone the nucleic acid amplified by polychlorinated biphenyls (a series of nuclear information acids above A9) to produce a building;(c) Test the composition and inductive performance of at least one tnfalf production line obtained in paragraph (b); and