A Solid Pharmaceutical composition containing a water soluble Taxoide and a Cyclodextrin, its solutions in aqueous Solvents for usoparenteral, a process for its preparationA method for preventing the self Aggregation and precipitation of a premature Taxoide Group delpaclita

摘要

Water soluble solid pharmaceutical ingredients, including an aqueous solution of taxonomic sterols and cyclopentanediol and their solutions, are used as steroids: (a) as an active ingredient, it contains taxonomic sterols, such as paclitaxel and small taxonomic sterols, widely distributed, with large surface area, amoxicillin, preferably liaofeihua, It may exist in the form of salt or multi-form hydrate or solution, for example, the solution made of conetano and (b) contains fine acetyl gamma cyclopentadiol or hydroxypropyl beta cyclopentadiol (hereinafter referred to as cyclopentadiol), which can split the epidermis, AMOLIN, and preferably liofilizada,the weight ratio being between the mentioned taxoid and the cyclodextrininated from 1:25 to 1: 250; C) and eventually contain other auxiliary materials soluble in water and usually used in medicines intended for parenteral administration. In particular, the pharmaceutical composition contains as active ingredient paclitaxel and acetyl-gamma-cyclodextrin in a weight ratio of 1: 100 to 1: 150,or docetaxel and hydroxypropyl-beta-cyclodextrin in a weight ratio of 1:25 to 1: 100. The pharmaceutical composition may contain as cyclodextrin any of the following components: acetyl-gamma-cyclodextrin with an acetylation degree comprised between about 2 and about 12 groups per cyclodextrin ring, acetyl-gamma-cyclodextrin with an acetylation degree of approximately 8 gruposacetyl per cyclodextrin ring, hydroxy-propyl-beta-cyclodextrin with a degree of substitution between about 2 and about 10 hydroxypropyl groups per cyclodextrin ring,hydroxy-propyl-beta-cyclodextrin with a degree of substitution between about 4 and about 6 hydroxypropyl groups per cyclodextrin ring. A process for preparing a pharmaceutical composition in solid and instantaneously soluble state as mentioned above, and its solutions in aqueous solvents for parenteral use, process in which: a) dissolves