Combination of a selective antagonist of 5HT1a Receptors and an antagonist or partial agonist Selective 5-ht1b H5 -, Process for their preparation, Pharmaceutical formulations containing Said,Its use for the manufacture of a Medicament for the treatment of Affective Disorders and Kit containing Said Comb

摘要

Combining the counterpart of a counterpart country with the counterpart of a counterpart country or part of the counterpart country, the counterpart country of the counterpart country, the first component (a),It is a selective 5-HT1A diagonal, in which R1 is n-rpopil or cyclohexane, R2 is isopropyl, tert butyl, cyclohexane, tomato or cyclohexane, R3 is hydrological gene, R4 is hydrogen or methyl, and it is a dwarf form.And diagonal or partial patient receivers, second (b) part,This is a selective or partial h5-htm1b type stratosphere, containing grade II formula, in which X is CH2, O; and CONH, nhco, nhco; R1 is h, C1-6, cyclopropyl compound C3-6, R2 is h, C1-6, alcox C1-6, halogen; R3 is formula III; R4 and R5 are independent h or C1-4, racemato type asphalt, R - or enantiomero s - and the forms of (a) and (b) of these ingredients are free, soluble or pharmaceutically acceptable salts, their production processes, pharmaceutical formulations containing this mixture, use and treatment of induced disorders such as depression, anxiety, etc That combinationA toolkit containing such combinations and methods to improve the initiation of treatment methods.