Process for the preparation of pharmaceutical dosage units containing, as active substance, 11 - methylene - 17 Alpha Ethinyl estra - 17alfa hydroxy - 4.5 - diene - 3-one (org 30659)A Granulate which comprises 0.005 to 1096 in weight of org 30659 Micronized and a package that includes a PL

摘要

A process for the preparation of pharmaceutical dosage units containing, as active substance, 0.005 to 1.96 in weight 11 - methylene 17alfa Ethinyl estra - 17 beta - hydroxy - 415 - diene - 3-one (org 30659 Micronized)Comprising (a) a step of mixing involves joining the substance triggered by appropriate fillers to form a mixture and (b) a step of granulation in the mixture is granulated to formGlomerados or moistening the Granules with a Liquid Binder, Wetting and stirringWhere the granulation STEP (b) is performed so as to exert a Force on losgru00e1nulos Shear that exceeds the tensile strength of granules or agglomerates.The Procedure leads to Granules and Tablets have an excellent uniformity of content. A Granulate which comprises 0.005 to 1% by weight of 30659 Micronized org.