Aminoalquilfenol derived compounds useful for improving Memory dysfunction and Depression, intermediaries, depreparacion Procedure of such compounds.Pharmaceutical compositions and uses that include to make a Medicine for Treatment of depression and

摘要

Aminocresol compounds (1) extracted from the formula,Among them: R1 is a hydrogen, low tar, conr6r7, ch2coor8, ch2ch2oh, ch2cn or ch2c (=) c-r9, which is used to prepare (2) or a group of Si (R11) 3; R2 is a hydrogen, tar below C1-10, conr6r7, so2r10, which is used to prepare (3) or a group of Si (R11) 3; R3 is a liquefied gas or a tar below C1-10; R4 is a C15 below C15 C1-10 low level, formula (4),O design (5);R4 and R5 form formula (6) together with the nitrogen atoms connected together,Formula (7)Formula (8)Design (9);R6 is a hydrogen or a lower C1-10; R7 is C1-10, formula (10),Formula (11)O design (12);R6 and R7, together with the nitroglycerin atoms to which they attach, formanfoma (13);R8 is asphalt below C1-10; R9 is hydrogen, formula C (R14),Oh, formula (14),Design (15);R10 is the tar below C1-10; R11 is the tar below C1-10; R12 is the tar below C1-10, with lower hydroxyl group. Prepare cor15, prepare (16),Equation (17), equation (18),Equation (19),O design (20);R13 is hydrogen or lower hydrocarbon of C1-10; R14 is hydrogen or lower hydrocarbon of C1-10; R14 is hydrogen or lower hydrocarbon of C1-10; R15 is equation (21) or lower hydrocarbon of C1-10; R20 is lower plasma of C1-10; X is hydrogen or halogen; Z is hydrogen, halogen, lower hydrocarbon of C1-10, hydroxyl, hypoxic group, methylene trifluoride, nitrate or cyanogen, R20co or ocon6r7; m is 1 or 2; n is 0 or 1; P is 1 or 2; q is 0, 1 or 2; R is 0, 1 or 2; optical isomer or its pharmaceutically acceptable salts. Formula middleman: (22) where R16 and R17 are independent hydrogen or C1-10 and R18 are formula (23),W is hydrogen, low tar, low oxygen, hydrogen Xi, halogen or trifluoromethyl I and s are 1 or 2; X is hydrogen or halogen; m is 1 or 2; optical susisomeros or its pharmaceutically acceptable salt. Preparation intermediary: (24)Among them: R1 is the lower tar, bencilo, ch2c ch formula or former r6r7, R6 is hydrogen, R7 is the lower C1-10 tar; R2 is hydrogen, the lower C1-10 tar, design Si (R11) 3, R11 is the lower C1-10 tar