Compounds 2, trans - (4-aminocyclohexyl) amino - disustituidas purines 6.9,Pharmaceutical compositions and use of such compounds for the preparation of a Medicament for treating a disorder hiperproliferativo,To prevent apoptosis in neuronal cells and protect the cells neuronale

摘要

Compounds of formula (i) wherein R is selected from the group consisting of R2, r2nh -Or r3r4n R5 - Where R2 is selected from the group formed poralquilo c9-12 of formula (ii) wherein R6 is selected independently from each group comprising Hydrogen, cycloalkyl C3 - 8C1-4 alkyl, and mfenilo (CH2), where a whole month 0 - 8; X is an integer - 1; n is integer 0 - 8; is selected from the group consisting of phenyl Heterocyclic cycloalkyl,,,Ynaftaleno; M is selected from the grupofo confirmed by Hydrogen, c1-4 alkyl, where each R6 is selected regardless of porhidrogeno cycloalkyl Group, C3 - 8C1-4 alkyl and phenyl - (CH2) m, where M is an integer of 0 - 8; n is an integer of 0 - 8; X is an integer Q 1 - 8; eshidrogeno or c1-4 alkyl; and Z is selected from the group consisting of phenyl Heterocycles.Cycloalkyl and alkyl naphthalene; and when each c9-12 or z is optionally substituted with 1 to 3 substituents, which can be same or different,And two are selected from the group formed by D, e, fig.III D seleccionadoindependientemente where each group is formed by trifluormetilo, trifluormetoxi c1-4 alkoxy, and E is selected independently; each group formed by Oh, Hal,Yalquilo C1 - 8; an integer B and S = - 2; Z is selected from the group consisting of phenyl Heterocycles.Cycloalkyl and R6 is seleccionadoindependientemente naphthalene; each group formed by Hydrogen, alkyl, cycloalkyl C1 - C3 - 8, 4 and M - (CH2) phenylWhere M is a Body ro 0 - 8; n is an integer of 0 - 8; X is an integer 1 to 8, and M is selected from the group consisting of hydrogen, c1-4 alkyl, formula IV,R6 is selected regardless where each group formed by Hydrogen, alkyl, cycloalkyl C1 - C3 - 8, 4 and (CH2) M phenylWhere M is a - 8 January 0; X is an integer 1 - 8; and q is Hydrogen or alquiloc1 - 4; and Z is selected from the group consisting of Heterocyclic cycloalkyl, phenyl and naphthaleneWhere the groups M and z can estarsustituidosopcionalmente with groups or Formula D and V where each R6 is selected regardless of the group consisting of hydrogen, cycloalkyl C3 - 8