Compounds 8 - alkoxy - or 8 - tioalquil quinolin-1 - 5 - carboxamide, useful as TNF inhibitors and as PDE IV inhibitors.These compounds and Pharmaceutical compositions formuladascon use of these compounds for the manufacture of drugs to modulate the inhibition of fosfodiestearasa IV and the fact

摘要

These compounds of the General formula (i) wherein R IS h, alkyl or Halogen; r1 represents opocionalmente Oh, alkoxy, substituted with one or mu00e1shalogenos R2, or tioalquilo;R3 and R4 are same or different and each h, R7, or11, cor7, C (= nor7) R7 alkyl, - C (= nor7 Cf3) R7 Halogen, alkyl, - C (= Noh) R7, C (= Noh) R7, CN, CO2H, co2r11, CONH2, conhr7 with (R7) 2Nr9r10 or conr12r13 where nr12r13 is a Heterocyclic Ring optionally substituted with one or more r5es R15; h, arylalkyl, heteroarilaquilo, heterocicloalquilo s (o) mr12r13, CN, Oxygen carbonylNr9r10, cor11 and S (OR) nr; R6 h, arylalkyl, heteroarilalquilo oheterocicloalquilo in R5 and R6 /; or,The heterocycle aryl heteroaryl / / fraction is optionally substituted with one or more alkyl substituents or R14 R14.Loscompuestos can be used for treating disease States, including disease States associated with Proteins that mediate Cellular activityDistrict inhibition of tumor necrosis factor and / or by inhibition of phosphodiesterase IV.